Clinical evaluation of the use of inhalation of 6% N-acetylcysteine in 3% NaCL solution (Flu-Acyl Broncho) in the treatment of children with acute bronchitis

Purpose - to propose an optimization of treatment acute bronchitis in children by introducing inhalation FLU-ACIL broncho before therapy. Materials and methods. An open, prospective, multicenter, non-interventional, comparative (with active control) study with two therapeutic groups was conducted. The experience therapy 45 moderate aged 2-12 years old summarized. main group included 30 who received Flu-Acyl Broncho the complex treatment: 5 ml 2 times a day 3-4 hours bedtime for 7-10 days; comparison 15 oral acetylcysteine/ambroxol 7-12 days. If it is necessary, antipyretic ibuprofen or paracetamol used. period from onset disease participation about 2-4 did not include concomitant middle ear diseases, sinusitis, allergic diseases symptoms obstruction. results examination patients were analyzed using software package «Statistica 6.0 Windows». Results conclusions. Comprehensive administration Broncho, sterile solution nebulizer instillation, has positive clinical effect, leads faster relief (p<0.01) disappearance (p<0.05) cough compared mucolytics. additional anti-inflammatory mucolytic effect route on nasopharyngeal mucosa improves respiratory pathology upper tract. This manifested faster, mucolytics, elimination rhinitis (p<0.001) sore throat (p<0.05). All studies performed accordance ethical principles adopted Declaration Helsinki Good Clinical Practice (GCP) medical research conducted human subjects. Approval obtained ethics committee Children’s Hospital No. Sviatoshynskyi district Kyiv. No conflict interests declared authors.